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Pico-Device Co.(English)
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Founded in 2003.

Address: Nagoya Life Science Incubation, Chigusa-cho 2-22-8, Chigusa-ku,

Nagoya 464-0858, Japan      Phone (0)52-735-7327, Fax (0)52-526-8616

Home page: http://www.pico-device.co.jp; mail address: pico@pico-device.co.jp




 Pico-Device Co. is a bencher company from Nagoya Institute of Technology.
Advanced techniques based on the gas emanated from human skin, called “skin gas” have been developed in University. We find several skin gases, such as hydrogen gas, methane gas, acetone vapor, ammonia gas, alcohol vapor, rose flavor compounds, allyl methyl sulfide vapor, nitric oxide gas, carbon monoxide gas and etc.



 Most of basic techniques are patented by Japan Science and Technology Agency and the president of Pico-Device Co. The patents are four Japanese patents, three US patents, four Korean patents (three registered and one is on the process), four European Patents (one registered, three are granted and under registration).



 Skin gases are really new concept. They could be used in the field of medical care and the promotion of human health. The relation ships of the amounts of skin gas acetone and ammonia gases with the health condition have been studied in hospital. The concentration of skin gas acetone, which way of collecting is shown in the photo, is well related with diabetes (N.Yamane et al., Clinica Chimica Acta, 365, 325-329, 2006). It could become a marker of diabetic control and of ketone production in diabetes and other ketogenic conditions. Skin gas ammonia has a good relationship with that in blood.


( Photo shows the collection of skin gas from hand for 3 min., and then it subject to analysis. )





 The present inventions relate to devices for collecting skin permeable gases and apparatus for measuring such skin permeable gases, wherein the device and apparatus are used to determine the health conditions.




 In very small compartment、sample gases (25-100ml) were cooled down and concentrated with 300 to 1000times, then the cold trap was electrically heated up with pulsed electric current under temperature controlling by the variation of electric resistance of cold trap. This new device is very powerful for rapid determination of volatile organic compound in air, skin permeable gases, breath gases, and the vapor coming from wood, wall, houses and etc.
 We have commercial cold trap instrument connected easily conventional GC or GC/MS.



 The recent commercialized chewing gum containing rose flavor, which has been co-developed with Kracie foods company (former name Kanebo Company) is one of the first attempt to realize a flavor food. The concentration of the flavor in skin gas after intake of the gum is enough to sense it for human being.



 Pico-Device Co. is the company doing consulting for analytical instrumentation and solving the trace determination of chemical compounds. We also are challenging to design a new instrumentation with high sensitivity.




 Sweat is including a lot of information of health conditions. For example, the ratio of sodium and potassium ion is an indicator for the activity of sweat grant, and the concentration of chloride ion is related with chronic pancreatitis. In future sweat analysis will help the monitoring of health condition at home.






   ・Japan  JP 4024818, JP 4024817, JP 3850662, JP 4057039

   ・US     US 7,247,137 B2, US 7,266,404 B2, 7,261,692 B2

   ・Germany  EP 1,357,376 B1, EP 1,746,406 B1

   ・Korea     572,548, 547,462, 592,212

 On-line Pre-concentration device for GC and GC/MS  US 6,661,241 B2



1.”New measurement of hydrogen gas and acetone vapor in gases emanating from human skin, K.Naitoh, T.Tsuda, K.Nose, T. Kondo, A.Takatsu, T.Hirabayashi, Instrumentation Science & technology, 30, 267-280(2002).

2.Assesment of colonic fermentation by hydrogen release from skin, T.Kondo, T.Tsuda, K.Nose, T.Ishiguro, T.Mitsui, K.P.Gao, K.Fijiki, American Journal of Gastroenterology, 97,1271-1272(2002).

3. "Relationship between skin acetone and blood beta-hydroxybutyrate concentrations in diabetes, "   Norio Yamane, Takao Tsuda, Kazutoshi Nose, Akiko Yamamoto, Hiroshi Ishiguro, Takaharu Kondo,:  Clinica Chimica Acta, (2006) 325 -329.

4. "Effects of Hypoxia on Nitric Oxide(NO) in Skin Gas and Exhaled Air " T.Ohkuwa, T.Mizuno, Y.Kato, K.Nose, H.Itoh, T.Tsuda : INTERNATIONAL JOURNAL of BIOMEDICAL SCIENCE November 2006 VOL.2 No.3

5. "Identification and Assessment of Carbon Monoxide in Gas Emanated from Human Skin" K.Nose, H.Ueda, T.Ohkuwa, T.Kondo, S.Araki, H.Ohtani, T.Tsuda, CHROMATOGRAPHY Journal of Separation and Detection Sciences Vol.27,No.2,2006 63-65

6. "Effect of hypoxia on expired nitric oxide in normal breathing, deep breathing and breath-holding," Tetsuo Ohkuwa, Tatsuo Mizuno, Yuji Kato, Kazutoshi Nose, Hiroshi Itoh, Takao Tsuda, International Journal of Fitness 1: 77-85, (2006)

7. "Identification of Gas Emanated from Human Skin: Methane, Ethylene, and Ethane," Kazutoshi Nose, Yoko Nunome, Takaharu Kondo, Shuki Araki, Takao Tsuda, :Analytical Sciences, 21, 625~628 (2005).

8. "Identification of ammonia in gas emanated from human skin and its correlation with that in blood," Kazutoshi Nose, Tatsuo Mizuno, Norio Yamane, Takaharu Kondo, Hajime Ohtani, Shuki Araki, Takao Tsuda, :ANALYTICAL SCIENCES December 2005 Vol.21,1471-1474.

9. "Relationship between Concentrations of Acetone Vapor Emanated from Human Skin and β-Hydroxybutyrate in Blood"K.Nose, T.Kondo, S.Araki, T.Tsuda: :BUNSEKI KAGAKU,54(2),161-165,2005 (In Japanese).

10. "Finding of several chemical gases emanated from human skin, called skin gas, and its flavor after intake of food containing flavor compounds" Takao Tsuda in AROMA RESEATCH 33, 63-72. and in Japanese with English abstract



 Our staff presented a brief introduction of human skin gas, which is emanated from human skin at Pittscon 2009, at the boots “JST Technology for your next innovation” at March 10,2009.



 
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